Testing for differences in polygenic scores in the presence of confounding.

ABSTRACT: Polygenic scores have become an important tool in human genetics, enabling the prediction of individuals' phenotypes from their genotypes. Understanding how the pattern of differences in polygenic score predictions across individuals intersects with variation in ancestry can provide insights into the evolutionary forces acting on the trait in question, and is important for understanding health disparities. However, because most polygenic scores are computed using effect estimates from population samples, they are susceptible to confounding by both genetic and environmental effects that are correlated with ancestry. The extent to which this confounding drives patterns in the distribution of polygenic scores depends on patterns of population structure in both the original estimation panel an

SUBMITTER: Blanc J 

PROVIDER: S-EPMC10055004 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature