Stability and heterogeneity in the anti-microbiota reactivity of human milk-derived Immunoglobulin A.

ABSTRACT: Immunoglobulin A (IgA) is secreted into breast milk and is critical to both protecting against enteric pathogens and shaping the infant intestinal microbiota. The efficacy of breast milk-derived maternal IgA (BrmIgA) is dependent upon its specificity, however heterogeneity in BrmIgA binding ability to the infant microbiota is not known. Using a flow cytometric array, we analyzed the reactivity of BrmIgA against bacteria common to the infant microbiota and discovered substantial heterogeneity between all donors, independent of preterm or term delivery. We also observed intra-donor variability in the BrmIgA response to closely related bacterial isolates. Conversely, longitudinal analysis showed that the anti-bacterial BrmIgA reactivity was relatively stable through time, even between sequent

SUBMITTER: Johnson-Hence CB 

PROVIDER: S-EPMC10055037 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature