Hardwired to attack: Transcriptionally defined amygdala subpopulations play distinct roles in innate social behaviors.

ABSTRACT: Social behaviors are innate and supported by dedicated neural circuits, but it remains unclear whether these circuits are developmentally hardwired or established through social experience. Here, we revealed distinct response patterns and functions in social behavior of medial amygdala (MeA) cells originating from two embryonically parcellated developmental lineages. MeA cells in male mice that express the transcription factor Foxp2 (MeA^Foxp2) are specialized for processing male conspecific cues even before puberty and are essential for adult inter-male aggression. In contrast, MeA cells derived from the Dbx1-lineage (MeA^Dbx1) respond broadly to social cues and are non-essential for male aggression. Furthermore, MeA^Foxp2 and MeA^Dbx1 cells

SUBMITTER: Lischinsky JE 

PROVIDER: S-EPMC10055059 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature