Ganglioside GD3 regulates neural stem cell quiescence and controls postnatal neurogenesis.

ABSTRACT: The postnatal neural stem cell (NSC) pool hosts quiescent and activated radial glia-like NSCs contributing to neurogenesis throughout adulthood. However, the underlying regulatory mechanism during the transition from quiescent NSCs to activated NSCs in the postnatal NSC niche is not fully understood. Lipid metabolism and lipid composition play important roles in regulating NSC fate determination. Biological lipid membranes define the individual cellular shape and help maintain cellular organization and are highly heterogenous in structure and there exist diverse microdomains (also known as lipid rafts), which are enriched with sugar molecules, such as glycosphingolipids. An often overlooked but key aspect is that the functional activities of proteins and genes are highly dependent upon the

SUBMITTER: Fuchigami T 

PROVIDER: S-EPMC10055067 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature