General and specific patterns of cortical gene expression as spatial correlates of complex cognitive functioning.

ABSTRACT: Gene expression varies across the brain. This spatial patterning denotes specialised support for particular brain functions. However, the way that a given gene's expression fluctuates across the brain may be governed by general rules. Quantifying patterns of spatial covariation across genes would offer insights into the molecular characteristics of brain areas supporting, for example, complex cognitive functions. Here, we use principal component analysis to separate general and unique gene regulatory associations with cortical substrates of cognition. We find that the region-to-region variation in cortical expression profiles of 8235 genes covaries across two major principal components : gene ontology analysis suggests these dimensions are characterised by downregulation and upregulation o

SUBMITTER: Moodie JE 

PROVIDER: S-EPMC10055068 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature