Germline-mediated immunoediting sculpts breast cancer subtypes and metastatic proclivity.

ABSTRACT: Cancer represents a broad spectrum of molecularly and morphologically diverse diseases. Individuals with the same clinical diagnosis can have tumors with drastically different molecular profiles and clinical response to treatment. It remains unclear when these differences arise during disease course and why some tumors are addicted to one oncogenic pathway over another. Somatic genomic aberrations occur within the context of an individual's germline genome, which can vary across millions of polymorphic sites. An open question is whether germline differences influence somatic tumor evolution. Interrogating 3,855 breast cancer lesions, spanning pre-invasive to metastatic disease, we demonstrate that germline variants in highly expressed and amplified genes influence somatic evolution by modu

SUBMITTER: Houlahan KE 

PROVIDER: S-EPMC10055121 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature