A Molecular, Spatial, and Regulatory Atlas of the <i>Hydra vulgaris</i> Nervous System.

ABSTRACT: Hydra vulgaris, a cnidarian with a simple nerve net, is an emerging model for developmental, regenerative, and functional neuroscience. Its genetic tractability and capacity for whole-system imaging make it well suited for studying neuron replacement, regeneration, and neural circuit function. Here, we present the most comprehensive molecular and spatial characterization of the H. vulgaris nervous system to date. Using single-cell RNA sequencing, we identified eight neuron types, each defined by distinct neuropeptide expression, and further resolved these into fifteen transcriptionally distinct subtypes with unique spatial distributions and morphologies. To investigate the gene regulatory networks underlying neuronal differentiation, we applied trajectory inference, identifie

SUBMITTER: Little HM 

PROVIDER: S-EPMC10055148 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature