Single-cell analysis of shared signatures and transcriptional diversity during zebrafish development.

ABSTRACT: During development, animals generate distinct cell populations with specific identities, functions, and morphologies. We mapped transcriptionally distinct populations across 489,686 cells from 62 stages during wild-type zebrafish embryogenesis and early larval development (3-120 hours post-fertilization). Using these data, we identified the limited catalog of gene expression programs reused across multiple tissues and their cell-type-specific adaptations. We also determined the duration each transcriptional state is present during development and suggest new long-term cycling populations. Focused analyses of non-skeletal muscle and the endoderm identified transcriptional profiles of understudied cell types and subpopulations, including the pneumatic duct, individual intestinal smooth muscl

SUBMITTER: Sur A 

PROVIDER: S-EPMC10055256 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature