Structural basis for functional properties of cytochrome c oxidase.

ABSTRACT: Cytochrome c oxidase (CcO) is an essential enzyme in mitochondrial and bacterial respiration. It catalyzes the four-electron reduction of molecular oxygen to water and harnesses the chemical energy to translocate four protons across biological membranes, thereby establishing the proton gradient required for ATP synthesis¹. The full turnover of the CcO reaction involves an oxidative phase, in which the reduced enzyme (R) is oxidized by molecular oxygen to the metastable oxidized O_H state, and a reductive phase, in which O_H is reduced back to the R state. During each of the two phases, two protons are translocated across the membranes². However, if O_H is allowed

SUBMITTER: Ishigami I 

PROVIDER: S-EPMC10055264 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature