Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1.

ABSTRACT: The intricate regulation of chromatin plays a key role in controlling genome architecture and accessibility. Histone lysine methyltransferases regulate chromatin by catalyzing the methylation of specific histone residues but are also hypothesized to have equally important non-catalytic roles. SUV420H1 di- and tri-methylates histone H4 lysine 20 (H4K20me2/me3) and plays crucial roles in DNA replication, repair, and heterochromatin formation, and is dysregulated in several cancers. Many of these processes were linked to its catalytic activity. However, deletion and inhibition of SUV420H1 have shown distinct phenotypes suggesting the enzyme likely has uncharacterized non-catalytic activities. To characterize the catalytic and non-catalytic mechanisms SUV420H1 uses to modify chromatin, we dete

SUBMITTER: Abini-Agbomson S 

PROVIDER: S-EPMC10055266 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature