Embryonic type 3 innate lymphoid cells sense maternal dietary cholesterol to control local Peyer's patch development.

ABSTRACT: Lymphoid tissue inducer (LTi) cells develop during intrauterine life and rely on developmental programs to initiate the organogenesis of secondary lymphoid organs (SLOs). This evolutionary conserved process endows the fetus with the ability to orchestrate the immune response after birth and to react to the triggers present in the environment. While it is established that LTi function can be shaped by maternal-derived cues and is critical to prepare the neonate with a functional scaffold to mount immune response, the cellular mechanisms that control anatomically distinct SLO organogenesis remain unclear. We discovered that LTi cells forming Peyer's patches, gut-specific SLOs, require the coordinated action of two migratory G protein coupled receptors (GPCR) GPR183 and CCR6. These two GPCRs

SUBMITTER: Howley K 

PROVIDER: S-EPMC10055282 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature