Frequent transitions in mating-type locus chromosomal organization in Malassezia and early steps in sexual reproduction.

ABSTRACT: Fungi in the basidiomycete genus Malassezia are the most prevalent eukaryotic microbes resident on the skin of human and other warm-blooded animals and have been implicated in skin diseases and systemic disorders. Analysis of Malassezia genomes revealed that key adaptations to the skin microenvironment have a direct genomic basis, and the identification of mating/meiotic genes suggests a capacity to reproduce sexually, even though no sexual cycle has yet been observed. In contrast to other bipolar or tetrapolar basidiomycetes that have either two linked mating-type-determining ( MAT ) loci or two MAT loci on separate chromosomes, in Malassezia species studied thus far the two MAT loci are arranged in a pseudobipolar configuration (linked on the sam

SUBMITTER: Coelho MA 

PROVIDER: S-EPMC10055393 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature