An intracellular phosphorus-starvation signal activates the PhoB/PhoR two-component system in Salmonella enterica.

ABSTRACT: Bacteria acquire P primarily as inorganic orthophosphate (Pi, PO₄^3-). Once internalized, Pi is rapidly assimilated into biomass during the synthesis of ATP. Because Pi is essential, but excessive ATP is toxic, the acquisition of environmental Pi is tightly regulated. In the bacterium Salmonella enterica (Salmonella), growth in Pi-limiting environments activates the membrane sensor histidine kinase PhoR, leading to the phosphorylation of its cognate transcriptional regulator PhoB and subsequent transcription of genes involved in adaptations to low Pi. Pi limitation is thought to promote PhoR kinase activity by altering the conformation of a membrane signaling complex comprised by PhoR, the multicomponent Pi transporter system PstSACB and the regulatory pr

SUBMITTER: Bruna RE 

PROVIDER: S-EPMC10055408 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature