Activity-dependent subcellular compartmentalization of dendritic mitochondria structure in CA1 pyramidal neurons.

ABSTRACT: Neuronal mitochondria play important roles beyond ATP generation, including Ca²⁺ uptake, and therefore have instructive roles in synaptic function and neuronal response properties. Mitochondrial morphology differs significantly in the axon and dendrites of a given neuronal subtype, but in CA1 pyramidal neurons (PNs) of the hippocampus, mitochondria within the dendritic arbor also display a remarkable degree of subcellular, layer-specific compartmentalization. In the dendrites of these neurons, mitochondria morphology ranges from highly fused and elongated in the apical tuft, to more fragmented in the apical oblique and basal dendritic compartments, and thus occupy a smaller fraction of dendritic volume than in the apical tuft. However, the molecular mechanisms underlying this st

SUBMITTER: Virga DM 

PROVIDER: S-EPMC10055421 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature