Association of rare variants in ARSA with Parkinson's disease.

ABSTRACT:

Background

Several lysosomal genes are associated with Parkinson's disease (PD), yet the association between PD and ARSA , which encodes for the enzyme arylsulfatase A, remains controversial.

Objectives

To evaluate the association between rare ARSA variants and PD.

Methods

To study possible association of rare variants (minor allele frequency<0.01) in ARSA with PD, we performed burden analyses in six independent cohorts with a total of 5,801 PD patients and 20,475 controls, using optimized sequence Kernel association test (SKAT-O), followed by a meta-analysis.

Results

We found evidence for an association between functional ARSA variants and PD in four independent cohorts (P≤0.05 in each) and in the meta-analysis (P=0.042). We also fo

SUBMITTER: Senkevich K 

PROVIDER: S-EPMC10055435 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature