Testing a polygenic risk score for morphological microglial activation in Alzheimer's disease and aging.

ABSTRACT: Neuroinflammation and the activation of microglial cells are among the earliest events in Alzheimer's disease (AD). However, direct observation of microglia in living people is not currently possible. Here, we indexed the heritable propensity for neuroinflammation with polygenic risk scores (PRS), using results from a recent genome-wide analysis of a validated post-mortem measure of morphological microglial activation. We sought to determine whether a PRS for microglial activation (PRS _mic ) could augment the predictive performance of existing AD PRSs for late-life cognitive impairment. First, PRS _mic were calculated and optimized in a calibration cohort (Alzheimer's Disease Neuroimaging Initiative (ADNI), n=450), with resampling. Second, predictive performance of opt

SUBMITTER: Tio ES 

PROVIDER: S-EPMC10055438 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature