Lineage-informative microhaplotypes for spatio-temporal surveillance of Plasmodium vivax malaria parasites.

ABSTRACT: Challenges in understanding the origin of recurrent Plasmodium vivax infections constrains the surveillance of antimalarial efficacy and transmission of this neglected parasite. Recurrent infections within an individual may arise from activation of dormant liver stages (relapse), blood-stage treatment failure (recrudescence) or new inoculations (reinfection). Molecular inference of familial relatedness (identity-by-descent or IBD) based on whole genome sequence data, together with analysis of the intervals between parasitaemic episodes ("time-to-event" analysis), can help resolve the probable origin of recurrences. Whole genome sequencing of predominantly low-density P. vivax infections is challenging, so an accurate and scalable genotyping method to determine the origins of

SUBMITTER: Siegel SV 

PROVIDER: S-EPMC10055443 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature