Multiomics integration of 22 immune-mediated monogenic diseases reveals an emergent axis of human immune health.

ABSTRACT: Monogenic diseases are often studied in isolation due to their rarity. Here we utilize multiomics to assess 22 monogenic immune-mediated conditions with age- and sex-matched healthy controls. Despite clearly detectable disease-specific and "pan-disease" signatures, individuals possess stable personal immune states over time. Temporally stable differences among subjects tend to dominate over differences attributable to disease conditions or medication use. Unsupervised principal variation analysis of personal immune states and machine learning classification distinguishing between healthy controls and patients converge to a metric of immune health (IHM). The IHM discriminates healthy from multiple polygenic autoimmune and inflammatory disease states in independent cohorts, marks healthy agi

SUBMITTER: Sparks R 

PROVIDER: S-EPMC10055521 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature