Genomic transcription factor binding site selection is edited by the chromatin remodeling factor CHD4.

ABSTRACT: Biologically precise enhancer licensing by lineage-determining transcription factors enables activation of transcripts appropriate to biological demand and prevents deleterious gene activation. This essential process is challenged by the millions of matches to most transcription factor binding motifs present in many eukaryotic genomes, leading to questions about how transcription factors achieve the exquisite specificity required. The importance of chromatin remodeling factors to enhancer activation is highlighted by their frequent mutation in developmental disorders and in cancer. Here we determine the roles of CHD4 to enhancer licensing and maintenance in breast cancer cells and during cellular reprogramming. In unchallenged basal breast cancer cells, CHD4 modulates chromatin accessibili

SUBMITTER: Saotome M 

PROVIDER: S-EPMC10055546 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature