Reduced control of SARS-CoV-2 infection is associated with lower mucosal antibody responses in pregnant women.

ABSTRACT:

Importance

Pregnant women are at increased risk of severe COVID-19, but the contribution of viral RNA load, the presence of infectious virus, and mucosal antibody responses remain understudied.

Objective

To evaluate the association of COVID-19 outcomes following confirmed infection with vaccination status, mucosal antibody responses, infectious virus recovery and viral RNA levels in pregnant compared with non-pregnant women.

Design

A retrospective observational cohort study of remnant clinical specimens from SARS-CoV-2 infected patients between October 2020-May 2022.

Setting

Five acute care hospitals within the Johns Hopkins Health System (JHHS) in the Baltimore, MD-Washington, DC area.

Participants

Participants included confirmed SARS-CoV-2 infected pre

SUBMITTER: St Clair LA 

PROVIDER: S-EPMC10055594 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature