Poor Oral Health Is Associated with Worse Brain Imaging Profiles.

ABSTRACT:

Importance

Poor oral health is a modifiable risk factor that is associated with a variety of health outcomes. However, the relationship between oral and brain health is not well understood.

Objective

To test the hypothesis that poor oral health is associated with worse neuroimaging brain health profiles in persons without stroke or dementia.

Design

We conducted a 2-stage cross-sectional neuroimaging study using data from the UK Biobank (UKB). First, we tested for association between self-reported poor oral health and MRI neuroimaging markers of brain health. Second, we used Mendelian Randomization (MR) analyses to test for association between genetically-determined poor oral health and the same neuroimaging markers.

Setting

Ongoing population study in the Unite

SUBMITTER: Rivier CA 

PROVIDER: S-EPMC10055602 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature