Development and Validation of a Prognostic Risk Model Based on Nature Killer Cells for Serous Ovarian Cancer.

ABSTRACT: Nature killer (NK) cells are increasingly considered important in tumor microenvironment, but their role in predicting the prognosis of ovarian cancer has not been revealed. This study aimed to develop a prognostic risk model for ovarian cancer based on NK cells. Firstly, differentially expressed genes (DEGs) of NK cells were found by single-cell RNA-sequencing dataset analysis. Based on six NK-cell DEGs identified by univariable, Lasso and multivariable Cox regression analyses, a prognostic risk model for serous ovarian cancer was developed in the TCGA cohort. This model was then validated in three external cohorts, and evaluated as an independent prognostic factor by multivariable Cox regression analysis together with clinical characteristics. With the investigation of the underlying mec

SUBMITTER: Zhang C 

PROVIDER: S-EPMC10055736 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature