Direct formation of amide/peptide bonds from carboxylic acids: no traditional coupling reagents, 1-pot, and green† † Electronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d3sc00198a

ABSTRACT: Technology for generating especially important amide and peptide bonds from carboxylic acids and amines that avoids traditional coupling reagents is described. The 1-pot processes developed rely on thioester formation, neat, using a simple dithiocarbamate, and are safe and green, and rely on Nature-inspired thioesters that are then converted to the targeted functionality. Technology for generating especially important amide and peptide bonds from carboxylic acids and amines that avoids traditional coupling reagents is described.

SUBMITTER: Freiberg K 

PROVIDER: S-EPMC10055766 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature