Opioid-like adverse effects of tianeptine in male rats and mice.

ABSTRACT:

Rationale

Tianeptine is a mu-opioid receptor (MOR) agonist with increasing reports of abuse in human populations. Preclinical data regarding the abuse potential and other opioid-like adverse effects of tianeptine at supratherapeutic doses are sparse.

Objectives

The present study evaluated tianeptine in a rat model of abuse potential assessment and in mouse models of motor, gastrointestinal, and respiratory adverse effects.

Methods

Abuse potential was assessed in adult male Sprague-Dawley rats using an intracranial self-stimulation (ICSS) procedure to determine effects of acute and repeated tianeptine on responding for electrical brain stimulation. Male ICR mice were used to determine the effects of tianeptine in assays of locomotor behavior and gastrointestinal motili

SUBMITTER: Baird TR 

PROVIDER: S-EPMC10055856 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature