Surface Plasmon Resonance Sensor Based on Core-Shell Fe₃O₄@SiO₂@Au Nanoparticles Amplification Effect for Detection of T-2 Toxin.

ABSTRACT: In this paper, a core-shell based on the Fe₃O₄@SiO₂@Au nanoparticle amplification technique for a surface plasmon resonance (SPR) sensor is proposed. Fe₃O₄@SiO₂@AuNPs were used not only to amplify SPR signals, but also to rapidly separate and enrich T-2 toxin via an external magnetic field. We detected T-2 toxin using the direct competition method in order to evaluate the amplification effect of Fe₃O₄@SiO₂@AuNPs. A T-2 toxin-protein conjugate (T2-OVA) immobilized on the surface of 3-mercaptopropionic acid-modified sensing film competed with T-2 toxin to combine with the T-2 toxin antibody-Fe₃O₄@SiO₂@AuNPs conjugates (mAb-Fe₃O₄@SiO_2</

SUBMITTER: Fan L 

PROVIDER: S-EPMC10055945 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature