Pooled Analysis of Mesenchymal Stromal Cell-Derived Extracellular Vesicle Therapy for Liver Disease in Preclinical Models.

ABSTRACT:

Background

Although increasing preclinical studies have emphasized the benefits of exosome-related therapies, the efficacy of mesenchymal stromal cell (MSC)-derived extracellular vesicles (EV) for liver injury is unclear. In this work, a pooled analysis was conducted to explore the overall effect of MSC-EV in animal models.

Methods

A systematic search of the PubMed, EMBASE, Web of Science, and Cochrane Library databases was performed, from initiation to February 2022, for preclinical studies with liver disease models. The treatment outcomes were evaluated based on liver function, histological analysis, and inflammatory cytokines.

Results

After screening, 39 studies were included. Pooled analyses demonstrated that MSC-EV therapy significantly improved liver functions (

SUBMITTER: Fang X 

PROVIDER: S-EPMC10056150 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature