A Novel and Simplified Score for Determining Treatment Eligibility for Patients with Chronic Hepatitis B.

ABSTRACT: Background: International guidelines for hepatitis B infection (HBV) recommend initiating antiviral treatment based on viral replication with inflammation or fibrosis. HBV viral loads and liver fibrosis measurements are not widely available in resource-limited countries. Aim: To develop a novel scoring system for the initiation of antiviral treatment in HBV-infected patients. Methods: We examined 602 and 420 treatment-naïve, HBV mono-infected patients for derivation and validation cohorts. We performed regression analysis to identify parameters associated with the initiation of antiviral treatment based on the European Association for the Study of the Liver (EASL) guidelines. The novel score was developed based on these parameters. Results: The novel score (HePA

SUBMITTER: Geeratragool T 

PROVIDER: S-EPMC10056199 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature