Probabilistic Points of Departure and Reference Doses for Characterizing Human Noncancer and Developmental/Reproductive Effects for 10,145 Chemicals.

ABSTRACT:

Background

Regulatory toxicity values used to assess and manage chemical risks rely on the determination of the point of departure (POD) for a critical effect, which results from a comprehensive and systematic assessment of available toxicity studies. However, regulatory assessments are only available for a small fraction of chemicals.

Objectives

Using in vivo experimental animal data from the U.S. Environmental Protection Agency's Toxicity Value Database, we developed a semiautomated approach to determine surrogate oral route PODs, and corresponding toxicity values where regulatory assessments are unavailable.

Methods

We developed a curated data set restricted to effect levels, exposure routes, study designs, and species relevant for deriving toxicity values.

SUBMITTER: Aurisano N 

PROVIDER: S-EPMC10056221 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature