Therapeutic Vaccination in Head and Neck Squamous Cell Carcinoma-A Review.

ABSTRACT: Therapeutic vaccination is one of the most effective immunotherapeutic approaches, second only to immune checkpoint inhibitors (ICIs), which have already been approved for clinical use. Head and neck squamous cell carcinomas (HNSCCs) are heterogenous epithelial tumors of the upper aerodigestive tract, and a significant proportion of these tumors tend to exhibit unfavorable therapeutic responses to the existing treatment options. Comprehending the immunopathology of these tumors and choosing an appropriate immunotherapeutic maneuver seems to be a promising avenue for solving this problem. The current review provides a detailed overview of the strategies, targets, and candidates for therapeutic vaccination in HNSCC. The classical principle of inducing a potent, antigen-speci

SUBMITTER: Devaraja K 

PROVIDER: S-EPMC10056222 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature