Target-Based Anticancer Indole Derivatives for the Development of Anti-Glioblastoma Agents.

ABSTRACT: Glioblastoma (GBM) is the most aggressive and frequent primary brain tumor, with a poor prognosis and the highest mortality rate. Currently, GBM therapy consists of surgical resection of the tumor, radiotherapy, and adjuvant chemotherapy with temozolomide. Consistently, there are poor treatment options and only modest anticancer efficacy is achieved; therefore, there is still a need for the development of new effective therapies for GBM. Indole is considered one of the most privileged scaffolds in heterocyclic chemistry, so it may serve as an effective probe for the development of new drug candidates against challenging diseases, including GBM. This review analyzes the therapeutic benefit and clinical development of novel indole-based derivatives investigated as promising anti-GBM agents.

SUBMITTER: Salerno S 

PROVIDER: S-EPMC10056347 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature