DLC1 as Druggable Target for Specific Subsets of Gastric Cancer: An RNA-seq-Based Study.

ABSTRACT: Background: Gastric cancer has been ranked the third leading cause of cancer death worldwide. Its detection at the early stage is difficult because patients mostly experience vague and non-specific symptoms in the early stages. Methods: The RNA-seq datasets of both gastric cancer and normal samples were considered and processed. The obtained differentially expressed genes were then subjected to functional enrichment analysis and pathway analysis. An implicit atomistic molecular dynamics simulation was executed on the selected protein receptor for 50 ns. The electrostatics, surface potential, radius of gyration, and macromolecular energy frustration landscape were computed. Results: We obtained a large number of DEGs; most of them were down-regulated, while few were up-

SUBMITTER: Yang L 

PROVIDER: S-EPMC10056469 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature