Leucocyte Abnormalities in Synovial Fluid of Degenerative and Inflammatory Arthropathies.

ABSTRACT: Genome damage has been related to the induction of autoimmune processes, chronic inflammation, and apoptosis. Recent studies suggest that some rheumatological diseases are associated with overall genomic instability in the T cell compartment. However, no data regarding leucocyte abnormalities in synovial fluid (SF) and their relationship with inflammation are available. The aim of this study was to investigate cellular phenotypes in SF collected from patients with different inflammatory arthropathies, including rhematoid arthritis (RA), psoriatic arthritis (PsA), crystal-induced arthritis (CIA), and non-inflammatory arthropathies, such as osteoarthritis (OA). We found high percentage of micronuclei in SF from CIA compared to the other groups and a high frequency of pyknotic cell in RA and

SUBMITTER: Baggio C 

PROVIDER: S-EPMC10056596 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature