Staphylococcus aureus Behavior on Artificial Surfaces Mimicking Bone Environment.

ABSTRACT: Infections, which interfere with bone regeneration, may be a critical issue to consider during the development of biomimetic material. Calcium phosphate (CaP) and type I collagen substrates, both suitable for bone-regeneration dedicated scaffolds, may favor bacterial adhesion. Staphylococcus aureus possesses adhesins that allow binding to CaP or collagen. After their adhesion, bacteria may develop structures highly tolerant to immune system attacks or antibiotic treatments: the biofilms. Thus, the choice of material used for scaffolds intended for bone sites is essential to provide devices with the ability to prevent bone and joint infections by limiting bacterial adhesion. In this study, we compared the adhesion of three different S. aureus strains (CIP 53.154, SH1000, and U

SUBMITTER: Lemaire A 

PROVIDER: S-EPMC10056644 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature