Cuminaldehyde Effects in a MIA-Induced Experimental Model Osteoarthritis in Rat Knees.

ABSTRACT: Osteoarthritis (OA) is a chronic degenerative disease that has a significant global impact. It is associated with aging and characterized by widespread joint destruction. Cuminaldehyde is a biologically active component of essential oils that has shown promise in the treatment of nociceptive and inflammatory diseases. This study investigated the effects of cuminaldehyde on an experimental model of osteoarthritis induced in rat knees. Cuminaldehyde was found to be as effective as indomethacin in reducing pain in all evaluated tests, including forced walking, functional disability of weight distribution on the legs, and spontaneous pain in animals with osteoarthritis. The knees of animals treated with cuminaldehyde had significantly higher radiographic and histopathological scores than those

SUBMITTER: Morais SV 

PROVIDER: S-EPMC10056807 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature