Pharmacology-Based Prediction of the Targets and Mechanisms for Icariin against Myocardial Infarction.

ABSTRACT: Background and Objectives: This study aims to illustrate the mechanisms underlying the therapeutic effect of Icariin after myocardial infarction (MI). Materials and Methods: Based on the network pharmacology strategy, we predict the therapeutic targets of Icariin against MI and investigate the pharmacological molecular mechanisms. A topological network was created. Biological process and Kyoto Encyclopedia of Genes and Genomes pathway enrichment were also performed. We also conducted the molecular docking analysis to stimulate the component-target interaction further and validate the direct bind effect. Results: Network pharmacology analysis identified 61 candidate genes related to the therapeutic effect of Icariin against MI. EGFR, AKT1, TP53,

SUBMITTER: Ke Z 

PROVIDER: S-EPMC10056910 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature