Molecular Evolutionary Analyses of the Pseudomonas-Derived Cephalosporinase Gene.

ABSTRACT: Despite the increasing evidence of the clinical impact of Pseudomonas-derived cephalosporinase (PDC) sequence polymorphisms, the molecular evolution of its encoding gene, bla_PDC, remains elusive. To elucidate this, we performed a comprehensive evolutionary analysis of bla_PDC. A Bayesian Markov Chain Monte Carlo phylogenetic tree revealed that a common ancestor of bla_PDC diverged approximately 4660 years ago, leading to the formation of eight clonal variants (clusters A-H). The phylogenetic distances within clusters A to G were short, whereas those within cluster H were relatively long. Two positive selection sites and many negative selection sites were estimated. Two PDC active sites overlapped with negative selection sites. In d

SUBMITTER: Shirai T 

PROVIDER: S-EPMC10057138 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature