Evolution and Progress of mRNA Vaccines in the Treatment of Melanoma: Future Prospects.

ABSTRACT: mRNA vaccines encoding tumor antigens may be able to sensitize the immune system of the host against cancer cells, enhancing antigen presentation and immune response. Since the breakout of the COVID19 pandemic, interest in mRNA vaccines has been accelerating, as vaccination against the virus served as a measure to limit disease spread. Given that immunotherapy has been the cornerstone of melanoma treatment over the last several decades, further innate immunity enhancement by targeted mRNA vaccines could be the next pivotal achievement in melanoma treatment. Preclinical data coming from murine cancer models have already provided evidence of mRNA vaccines' ability to induce host immune responses against cancer. Moreover, specific immune responses have been observed in melanoma patients recei

SUBMITTER: Bafaloukos D 

PROVIDER: S-EPMC10057252 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature