Effect of Frozen-Thawed Embryo Transfer on the Metabolism of Children in Early Childhood.

ABSTRACT:

Background

As a routine procedure in assisted reproductive technology (ART), it is crucial to assess the safety of frozen and thawed embryo transfer (FET). We aimed to investigate the metabolic profile of children conceived through FET in their early childhood.

Method

A total of 147 children between the age of 1.5 and 4 years old, conceived through FET or naturally conceived (NC), were recruited. A total of 89 children, 65 in the FET group and 24 in the NC group (matched with the FET group based on children's BMI) were included in the final statistical analysis of biochemical markers and metabolomics.

Results

Children conceived through FET had a lower level of fasting insulin level and HORM-IR and a higher level of fasting glucose and APOE as compared to children natu

SUBMITTER: Dong ZH 

PROVIDER: S-EPMC10057347 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature