Targeting Glioblastoma-Associated Macrophages for Photodynamic Therapy Using AGuIX^®-Design Nanoparticles.

ABSTRACT: Glioblastoma (GBM) is the most difficult brain cancer to treat, and photodynamic therapy (PDT) is emerging as a complementary approach to improve tumor eradication. Neuropilin-1 (NRP-1) protein expression plays a critical role in GBM progression and immune response. Moreover, various clinical databases highlight a relationship between NRP-1 and M2 macrophage infiltration. In order to induce a photodynamic effect, multifunctional AGuIX^®-design nanoparticles were used in combination with a magnetic resonance imaging (MRI) contrast agent, as well as a porphyrin as the photosensitizer molecule and KDKPPR peptide ligand for targeting the NRP-1 receptor. The main objective of this study was to characterize the impact of macrophage NRP-1 protein expression on the uptake of functionaliz

SUBMITTER: Lerouge L 

PROVIDER: S-EPMC10057379 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature