Analysis of Metabolite Distribution in Rat Liver of High-Fat Model by Mass Spectrometry Imaging.

ABSTRACT: Hyperlipidemia is a medical condition characterized by elevated levels of blood lipids, especially triglycerides (TG). However, it remains unclear whether TG levels remain consistently elevated throughout the entire developmental stage of the high-lipid state. In our animal experiment, we found that TG levels were significantly higher in the early stage of the high-lipid model but significantly decreased at the 14th week of the late stage, reaching levels similar to those of the control group. This suggests that TG levels in the high-lipid model are not always higher than those of the control group. To determine the reason for this observation, we used in situ mass spectrometry imaging (MSI) to detect the distribution of metabolites in the liver of rats. The metabolite distribution of the

SUBMITTER: Mao H 

PROVIDER: S-EPMC10057431 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature