The Exosome-Mediated PI3K/Akt/mTOR Signaling Pathway in Neurological Diseases.

ABSTRACT: As major public health concerns associated with a rapidly growing aging population, neurodegenerative diseases (NDDs) and neurological diseases are important causes of disability and mortality. Neurological diseases affect millions of people worldwide. Recent studies have indicated that apoptosis, inflammation, and oxidative stress are the main players of NDDs and have critical roles in neurodegenerative processes. During the aforementioned inflammatory/apoptotic/oxidative stress procedures, the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway plays a crucial role. Considering the functional and structural aspects of the blood-brain barrier, drug delivery to the central nervous system is relatively challenging. Exosomes are nanoscale memb

SUBMITTER: Iranpanah A 

PROVIDER: S-EPMC10057486 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature