The Biology of Stress Intolerance in Patients with Chronic Pain-State of the Art and Future Directions.

ABSTRACT: Stress has been consistently linked to negative impacts on physical and mental health. More specifically, patients with chronic pain experience stress intolerance, which is an exacerbation or occurrence of symptoms in response to any type of stress. The pathophysiological mechanisms underlying this phenomenon remain unsolved. In this state-of-the-art paper, we summarised the role of the autonomic nervous system (ANS) and hypothalamus-pituitary-adrenal (HPA) axis, the two major stress response systems in stress intolerance. We provided insights into such mechanisms based on evidence from clinical studies in both patients with chronic pain, showing dysregulated stress systems, and healthy controls supported by preclinical studies, highlighting the link between these systems and symptoms of s

SUBMITTER: Wyns A 

PROVIDER: S-EPMC10057496 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature