Association of Dengue Virus Serotypes 1&2 with Severe Dengue Having Deletions in Their 3'Untranslated Regions (3'UTRs).

ABSTRACT: Dengue virus infections are recorded as hyper-endemic in many countries, including India. Research pertaining to the reasons for frequent outbreaks and severe dengue is ongoing. Hyderabad city, India, has been recorded as a 'hotspot' for dengue virus infections. Dengue virus strains circulating over the past few years in Hyderabad city have been characterized at the molecular level to analyze the serotype/genotypes; 3'UTRs were further amplified and sequenced. The disease severity in patients infected with dengue virus strains with complete and 3'UTR deletion mutants was analyzed. Genotype I of the serotype 1 replaced genotype III, which has been circulating over the past few years in this region. Coincidentally, the number of dengue virus infections significantly increased in this region

SUBMITTER: Maisnam D 

PROVIDER: S-EPMC10057630 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature