The Effect of Potassium Nitrate Supplementation on the Force and Properties of Extensor digitorum longus (EDL) Muscles in Mice.

ABSTRACT: Adding potassium nitrate (KNO₃) to the diet improves the physiological properties of mammalian muscles (rebuilds weakened muscle, improves structure and functionality). The aim of this study was to investigate the effect of KNO₃ supplementation in a mouse model. BALB/c mice were fed a KNO₃ diet for three weeks, followed by a normal diet without nitrates. After the feeding period, the Extensor digitorum longus (EDL) muscle was evaluated ex vivo for contraction force and fatigue. To evaluate the possible pathological changes, the histology of EDL tissues was performed in control and KNO₃-fed groups after 21 days. The histological analysis showed an absence of negative effects in EDL muscles. We also analyzed 15 biochemical blood parameters.

SUBMITTER: Liubertas T 

PROVIDER: S-EPMC10057731 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature