Genetic Basis of Early Onset Atrial Fibrillation in Patients without Risk Factors.

ABSTRACT:

Background

Atrial fibrillation (AF) is the most common arrhythmia and typically occurs in elderly patients with other cardiovascular and extracardiac diseases. However, up to 15% of AF develops without any related risk factors. Recently, the role of genetic factors has been highlighted in this particular form of AF.

Aims

The aims of this study were to determine the prevalence of pathogenic variants in early-onset AF in patients without known disease-related risk factors and to identify any structural cardiac abnormalities in these patients.

Materials and methods

We conducted exome sequencing and interpretation in 54 risk factor-free early-onset AF patients and further validated our findings in a similar AF patient cohort from the UK Biobank.

Results

Pathogenic/

SUBMITTER: Rudaka I 

PROVIDER: S-EPMC10057774 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature