Dysregulation of Stress-Induced Translational Control by Porphyromonas gingivalis in Host Cells.

ABSTRACT: Porphyromonas gingivalis contributes to the chronic oral disease periodontitis, triggering the activation of host inflammatory responses, inducing cellular stresses such as oxidation. During stress, host cells can activate the Integrated Stress Response (ISR), a pathway which determines cellular fate, by either downregulating protein synthesis and initiating a stress-response gene expression program, or by initiating programmed cell death. Recent studies have implicated the ISR within both host antimicrobial defenses and the pathomechanism of certain microbes. In this study, using a combination of immunofluorescence confocal microscopy and immunoblotting, the molecular mechanisms by which P. gingivalis infection alters translation attenuation during oxidative stress-induced a

SUBMITTER: Knowles AA 

PROVIDER: S-EPMC10057856 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature