Animal Models for Studying Congenital Transmission of Hepatitis E Virus.

ABSTRACT: One of the most intriguing issues in the hepatitis E virus (HEV) field is the significant increase in mortality rates of the mother and fetus when infection occurs in the second and third trimesters of gestation. A virus that is normally self-limiting and has a mortality rate of less than one percent in otherwise healthy individuals steeply rises by up to 30% in these pregnant populations. Answering this pivotal question has not been a simple task. HEV, in general, has been a difficult pathogen to understand in the laboratory setting. A historical lack of ability to efficiently propagate the virus in tissue culture models has led to many molecular aspects of the viral lifecycle being understudied. Although great strides have been made in recent years to adapt viruses to cell culture, this

SUBMITTER: Yadav KK 

PROVIDER: S-EPMC10057890 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature