Automated Synthesis of [¹⁸F]Flumazenil Application in GABA_A Receptor Neuroimaging Availability for Rat Model of Anxiety.

ABSTRACT: Clinical studies have demonstrated that the γ-aminobutyric acid type A (GABA_A) receptor complex plays a central role in the modulation of anxiety. Conditioned fear and anxiety-like behaviors have many similarities at the neuroanatomical and pharmacological levels. The radioactive GABA/BZR receptor antagonist, fluorine-18-labeled flumazenil, [¹⁸F]flumazenil, behaves as a potential PET imaging agent for the evaluation of cortical damage of the brain in stroke, alcoholism, and for Alzheimer disease investigation. The main goal of our study was to investigate a fully automated nucleophilic fluorination system, with solid extraction purification, developed to replace traditional preparation methods, and to detect underlying expressions of contextual fear and characterize t

SUBMITTER: Farn SS 

PROVIDER: S-EPMC10058208 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature