Manganese Mediates Its Antiviral Functions in a cGAS-STING Pathway Independent Manner.

ABSTRACT: The innate immune system is the first line of host defense sensing viral infection. Manganese (Mn) has recently been found to be involved in the activation of the innate immune DNA-sensing cGAS-STING pathway and subsequent anti-DNA virus function. However, it is still unclear whether Mn²⁺ mediates host defense against RNA viruses. In this study, we demonstrate that Mn²⁺ exhibited antiviral effects against various animal and human viruses, including RNA viruses such as PRRSVs and VSV, as well as DNA viruses such as HSV1, in a dose-dependent manner. Moreover, cGAS and STING were both investigated in the Mn²⁺ mediated antiviral roles using the knockout cells made by the CRISPR-Cas9 approach. Unexpectedly, the results revealed that neither cGAS knockout nor STI

SUBMITTER: Sun S 

PROVIDER: S-EPMC10058264 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature