T Cell Responses Correlate with Self-Reported Disease Severity and Neutralizing Antibody Responses Predict Protection against SARS-CoV-2 Breakthrough Infection.

ABSTRACT:

Objectives

The objective of this prospective study was to investigate the role of adaptive immunity in response to SARS-CoV-2 vaccines.

Design and methods

A cohort of 677 vaccinated individuals participated in a comprehensive survey of their vaccination status and associated side effects, and donated blood to evaluate their adaptive immune responses by neutralizing antibody (NAb) and T cell responses. The cohort then completed a follow-up survey to investigate the occurrence of breakthrough infections.

Results

NAb levels were the highest in participants vaccinated with Moderna, followed by Pfizer and Johnson & Johnson. NAb levels decreased with time after vaccination with Pfizer and Johnson & Johnson. T cell responses showed no significant difference among the differe

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC10058409 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature